Amitriptyline
Guidance on Amitriptyline use with opiates
Background: A 48 Year old patient died due to coadministration of Oxycodone and Amitriptyline (Nov 2019), possibly due to over-sedation. The coroner criticised the lack of guidance on prescribing Amitriptyline and Oxycodone fromNICE and BNF (1). Amitriptyline found to be most common reason for antidepressant associated deaths. The highest morbidityamongst all classes of antidepressants was […]